| Function | Non-catalytic component of the METTL1-WDR4 methyltransferase complex required for the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). In the METTL1-WDR4 methyltransferase complex, WDR4 acts as a scaffold for tRNA-binding. Required for the formation of N(7)-methylguanine at position 46 (m7G46) in a large subset of tRNAs that contain the 5'-RAGGU-3' motif within the variable loop. M7G46 interacts with C13-G22 in the D-loop to stabilize tRNA tertiary structure and protect tRNAs from decay. Also required for the formation of N(7)-methylguanine at internal sites in a subset of mRNAs. Also required for methylation of a specific subset of miRNAs, such as let-7. Independently of METTL1, also plays a role in genome stability: localizes at the DNA replication site and regulates endonucleolytic activities of FEN1. |
| Protein Name | TrnaGuanine-N(7--Methyltransferase Non-Catalytic Subunit Wdr4Protein Wuho HomologHwhWd Repeat-Containing Protein 4 |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | NucleusChromosomeLocalizes At The Site Of Nascent Dna Synthesis |
| Alternative Antibody Names | Anti-Trna antibodyAnti-Guanine-N(7--Methyltransferase Non-Catalytic Subunit Wdr4 antibodyAnti-Protein Wuho Homolog antibodyAnti-Hwh antibodyAnti-Wd Repeat-Containing Protein 4 antibodyAnti-WDR4 antibody |
Information sourced from Uniprot.org
