| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-WASH complex subunit 5 (515-565 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
WASHC5 |
| Gene ID: |
9897 |
| Uniprot ID: |
WASC5_HUMAN |
| Immunogen Region: |
515-565 aa |
| Specificity: |
This antibody detects endogenous levels of STRUM at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human STRUM at the amino acid range 515-565 |
| Function | Acts as a component of the WASH core complex that functions as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. May be involved in axonal outgrowth. Involved in cellular localization of ADRB2. Involved in cellular trafficking of BLOC-1 complex cargos such as ATP7A and VAMP7. |
| Protein Name | Wash Complex Subunit 5StrumpellinWash Complex Subunit Strumpellin |
| Cellular Localisation | CytoplasmCytosolEndoplasmic ReticulumEarly EndosomeColocalizes With Syp/Synaptophysin In The External Molecular Layer Of The Dentate Gyrus And In Motoneurons Of The Ventral Horn Of Spinal Cord |
| Alternative Antibody Names | Anti-Wash Complex Subunit 5 antibodyAnti-Strumpellin antibodyAnti-Wash Complex Subunit Strumpellin antibodyAnti-WASHC5 antibodyAnti-KIAA0196 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
