| Short Description : | Rabbit polyclonal VWC2L (1-50) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Vwc2l |
| Gene ID: | 320460 |
| Uniprot ID: | VWC2L_MOUSE |
| Immunogen Region: | 1-50 |
| Immunogen Sequence: | MALHIHEACILLLVIPGLVT SAAISHEDYPADEGDQASSN DNLIFDDYRG |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-50 of mouse VWC2L (NP_796138.2). |
| Tissue Specificity | Predominantly expressed in the brain (at protein level). Also detected in bones, including femur and calvaria, heart, lung and kidney. Isoform 5 is predominant in lung and heart, compared to isoforms 1 and 3. Isoform 4 is expressed in femur and calvaria at higher levels than isoforms 1 and 5. Isoforms 1 and 4 are expressed at higher levels than isoform 5 in kidney and brain. |
| Function | May play a role in neurogenesis. May promote matrix mineralization, but has been shown to weakly, but significantly inhibit BMP2 and BMP6 activity in a preosteoblastic cell line. |
| Protein Name | Von Willebrand Factor C Domain-Containing Protein 2-LikeBrorin-Like |
| Database Links | |
| Cellular Localisation | SecretedSynapse |
| Alternative Antibody Names | Anti-Von Willebrand Factor C Domain-Containing Protein 2-Like antibodyAnti-Brorin-Like antibodyAnti-Vwc2l antibody |
Information sourced from Uniprot.org
