| Function | Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inhibition of SMAD2-dependent promoters, thus increasing SMAD2-dependent transcription. Does not affect TGF-beta-induced SMAD2 or SMAD3 phosphorylation, nor SMAD2/SMAD4 complex formation. Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Acts as a component of the putative HOPS endosomal tethering complex which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes. Required for fusion of endosomes and autophagosomes with lysosomes. |
| Protein Name | Vam6/Vps39-Like ProteinTrap1-Like ProteinHvam6p |
| Database Links | Reactome: R-HSA-9754560 |
| Cellular Localisation | CytoplasmLysosome MembranePeripheral Membrane ProteinLate Endosome MembraneColocalizes With Tgfbr1 And Tgfbr2 In Cytoplasmic Vesicular Structures And Most Prominently In Cortical Vesicles(Microbial Infection) Sequestrated At The Late Endosome By Sars Coronavirus-2/Sars-Cov-2 Orf3a Protein |
| Alternative Antibody Names | Anti-Vam6/Vps39-Like Protein antibodyAnti-Trap1-Like Protein antibodyAnti-Hvam6p antibodyAnti-VPS39 antibodyAnti-KIAA0770 antibodyAnti-TLP antibodyAnti-VAM6 antibody |
Information sourced from Uniprot.org
