| Host: |
Mouse |
| Applications: |
IHC-F/WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Vinculin is suitable for use in Immunohistochemistry, Western Blot and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
FB11 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 1% BSA & 0.1% sodium azide |
| Concentration: |
100 ug/mL |
| Dilution Range: |
IHC-FWB 1:1000ELISA |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
VCL |
| Gene ID: |
7414 |
| Uniprot ID: |
VINC_HUMAN |
| Immunogen: |
Vinculin purified from human smooth muscle |
| Tissue Specificity | Metavinculin is muscle-specific. |
| Post Translational Modifications | Phosphorylated.on serines, threonines and tyrosines. Phosphorylation on Tyr-1133 in activated platelets affects head-tail interactions and cell spreading but has no effect on actin binding nor on localization to focal adhesion plaques. Acetylated.mainly by myristic acid but also by a small amount of palmitic acid. |
| Function | Actin filament (F-actin)-binding protein involved in cell-matrix adhesion and cell-cell adhesion. Regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion. |
| Protein Name | VinculinMetavinculinMv |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-445355Reactome: R-HSA-5674135Reactome: R-HSA-6798695Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9725370 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic SideCell JunctionAdherens JunctionFocal AdhesionCytoplasmCytoskeletonSarcolemmaCell ProjectionPodosomeRecruitment To Cell-Cell Junctions Occurs In A Myosin Ii-Dependent MannerInteraction With Ctnnb1 Is Necessary For Its Localization To The Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Vinculin antibodyAnti-Metavinculin antibodyAnti-Mv antibodyAnti-VCL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
