Anti-VDR antibody (1-100) (STJ26084)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal VDR (1-100) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VDR |
| Gene ID | 7421 |
| Uniprot ID | VDR_HUMAN |
| Immunogen Region | 1-100 |
| Immunogen Sequence | MEAMAASTSLPDPGDFDRNV PRICGVCGDRATGFHFNAMT CEGCKGFFRRSMKRKALFTC PFNGDCRITKDNRRHCQACR LKRCVDIGMMKEFILTDEEV |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VDR (NP_000367.1). |
Additional Info
| Post Translational Modifications | Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound VDR when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation. |
| Function | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. |
| Protein Name | Vitamin D3 ReceptorVdr1 -25-Dihydroxyvitamin D3 ReceptorNuclear Receptor Subfamily 1 Group I Member 1 |
| Database Links | Reactome: R-HSA-196791Reactome: R-HSA-383280Reactome: R-HSA-4090294 |
| Cellular Localisation | NucleusCytoplasmLocalizes Mainly To The NucleusTranslocated Into The Nucleus Via Both Ligand-Dependent And Ligand-Independent PathwaysLigand-Independent Nuclear Translocation Is Mediated By Ipo4 |
| Alternative Antibody Names | Anti-Vitamin D3 Receptor antibodyAnti-Vdr antibodyAnti-1 -25-Dihydroxyvitamin D3 Receptor antibodyAnti-Nuclear Receptor Subfamily 1 Group I Member 1 antibodyAnti-VDR antibodyAnti-NR1I1 antibody |
Information sourced from Uniprot.org