Anti-VDAC3 antibody (1-283) (STJ112562)

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STJ112562
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:100-1:500
IHC-P:1:50-1:200
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: VDAC3
Gene ID: 7419
Uniprot ID: VDAC3_HUMAN
Immunogen Region: 1-283
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-283 of human VDAC3 (NP_005653.3).
Immunogen Sequence: MCNTPTYCDLGKAAKDVFNK GYGFGMVKIDLKTKSCSGVE FSTSGHAYTDTGKASGNLET KYKVCNYGLTFTQKWNTDNT LGTEISWENKLAEGLKLTLD TIFVPNTGKKSGKLKASYKR DCFSVGSNVDIDFSGPTIYG WAVLAFEGWLAGYQMSFDTA KSKLSQNNFALGYKAADFQL HTHVNDGTEFGGSIYQKVNE KIETSINLAWTAGSNNTRFG IAAKYMLDCRTSLSAKVNN
Tissue Specificity Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis.
Post Translational Modifications Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Function Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Involved in male fertility and sperm mitochondrial sheath formation.
Protein Name Voltage-Dependent Anion-Selective Channel Protein 3
Vdac-3
Hvdac3
Outer Mitochondrial Membrane Protein Porin 3
Database Links Reactome: R-HSA-5205685
Reactome: R-HSA-5689880
Reactome: R-HSA-8949215
Cellular Localisation Mitochondrion Outer Membrane
Membrane
May Localize To Non-Mitochondrial Membranes
Alternative Antibody Names Anti-Voltage-Dependent Anion-Selective Channel Protein 3 antibody
Anti-Vdac-3 antibody
Anti-Hvdac3 antibody
Anti-Outer Mitochondrial Membrane Protein Porin 3 antibody
Anti-VDAC3 antibody

Information sourced from Uniprot.org