| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VDAC3 |
| Gene ID: | 7419 |
| Uniprot ID: | VDAC3_HUMAN |
| Immunogen Region: | 1-283 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-283 of human VDAC3 (NP_005653.3). |
| Immunogen Sequence: | MCNTPTYCDLGKAAKDVFNK GYGFGMVKIDLKTKSCSGVE FSTSGHAYTDTGKASGNLET KYKVCNYGLTFTQKWNTDNT LGTEISWENKLAEGLKLTLD TIFVPNTGKKSGKLKASYKR DCFSVGSNVDIDFSGPTIYG WAVLAFEGWLAGYQMSFDTA KSKLSQNNFALGYKAADFQL HTHVNDGTEFGGSIYQKVNE KIETSINLAWTAGSNNTRFG IAAKYMLDCRTSLSAKVNN |
| Tissue Specificity | Expressed in erythrocytes (at protein level). Widely expressed. Highest in testis. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. Involved in male fertility and sperm mitochondrial sheath formation. |
| Protein Name | Voltage-Dependent Anion-Selective Channel Protein 3Vdac-3Hvdac3Outer Mitochondrial Membrane Protein Porin 3 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Voltage-Dependent Anion-Selective Channel Protein 3 antibodyAnti-Vdac-3 antibodyAnti-Hvdac3 antibodyAnti-Outer Mitochondrial Membrane Protein Porin 3 antibodyAnti-VDAC3 antibody |
Information sourced from Uniprot.org