| Host: |
Rabbit |
| Applications: |
WB/IHC-P/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
VDAC2 |
| Gene ID: |
7417 |
| Uniprot ID: |
VDAC2_HUMAN |
| Immunogen Region: |
14-24 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VDAC2 (NP_003366.2). |
| Immunogen Sequence: |
MATHGQTCARPMCIPPSYAD LGKAARDIFNKGFGFGLVKL DVKTKSCSGVEFSTSGSSNT DTGKVTGTLETKYKWCEYGL TFTEKWNTDNTLGTEIAIED |
| Tissue Specificity | Expressed in erythrocytes (at protein level). Expressed in all tissues examined. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. Binds various lipids, including the sphingolipid ceramide, the phospholipid phosphatidylcholine, and the sterols cholesterol and oxysterol. Binding of ceramide promotes the mitochondrial outer membrane permeabilization (MOMP) apoptotic pathway. Catalyzes the scrambling of phospholipids across the outer mitochondrial membrane.the mechanism is unrelated to channel activity and is capable of translocating both anionic and zwitterionic phospholipids. |
| Protein Name | Voltage-Dependent Anion-Selective Channel Protein 2Vdac-2Hvdac2Outer Mitochondrial Membrane Protein Porin 2 |
| Database Links | Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-8949215 |
| Cellular Localisation | Mitochondrion Outer MembraneMembraneMay Localize To Non-Mitochondrial Membranes |
| Alternative Antibody Names | Anti-Voltage-Dependent Anion-Selective Channel Protein 2 antibodyAnti-Vdac-2 antibodyAnti-Hvdac2 antibodyAnti-Outer Mitochondrial Membrane Protein Porin 2 antibodyAnti-VDAC2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
