Anti-VAPA antibody (34-84 aa) (STJ195181)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human VAPA at the amino acid range 34-84
General Information
| Short Description | Rabbit polyclonal anti-Vesicle-associated membrane protein-associated protein A (34-84 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | VAPA |
| Gene ID | 9218 |
| Uniprot ID | VAPA_HUMAN |
| Immunogen | Synthesized peptide derived from the human VAPA at the amino acid range 34-84 |
| Immunogen Region | 34-84 aa |
| Specificity | This antibody detects endogenous levels of VAPA at Human/Mouse/Rat |
Additional Info
| Function | Endoplasmic reticulum (ER)-anchored protein that mediates the formation of contact sites between the ER and endosomes via interaction with FFAT motif-containing proteins such as STARD3 or WDR44. STARD3-VAPA interaction enables cholesterol transfer from the ER to endosomes. Via interaction with WDR44 participates in neosynthesized protein export. In addition, recruited to the plasma membrane through OSBPL3 binding. The OSBPL3-VAPA complex stimulates RRAS signaling which in turn attenuates integrin beta-1 (ITGB1) activation at the cell surface. With OSBPL3, may regulate ER morphology. May play a role in vesicle trafficking. |
| Protein Name | Vesicle-Associated Membrane Protein-Associated Protein AVamp-AVamp-Associated Protein AVap-A33 Kda Vamp-Associated ProteinVap-33 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-6798695Reactome: R-HSA-9609523 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type Iv Membrane ProteinCell MembraneCell JunctionTight JunctionNucleus MembranePresent In The Plasma Membrane And In Intracellular VesiclesTogether With Snare ProteinsMay Also Associate With The CytoskeletonColocalizes With Ocln At The Tight Junction In Polarized Epithelial Cells |
| Alternative Antibody Names | Anti-Vesicle-Associated Membrane Protein-Associated Protein A antibodyAnti-Vamp-A antibodyAnti-Vamp-Associated Protein A antibodyAnti-Vap-A antibodyAnti-33 Kda Vamp-Associated Protein antibodyAnti-Vap-33 antibodyAnti-VAPA antibodyAnti-VAP33 antibody |
Information sourced from Uniprot.org