| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | VANGL2 |
| Gene ID: | 57216 |
| Uniprot ID: | VANG2_HUMAN |
| Immunogen Region: | 1-110 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-110 of human VANGL2 (NP_065068.1). |
| Immunogen Sequence: | MDTESQYSGYSYKSGHSRSS RKHRDRRDRHRSKSRDGGRG DKSVTIQAPGEPLLDNESTR GDERDDNWGETTTVVTGTSE HSISHDDLTRIAKDMEDSVP LDCSRHLGVA |
| Function | Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear. |
| Protein Name | Vang-Like Protein 2Loop-Tail Protein 1 HomologStrabismus 1Van Gogh-Like Protein 2 |
| Database Links | Reactome: R-HSA-4086400Reactome: R-HSA-4608870Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Vang-Like Protein 2 antibodyAnti-Loop-Tail Protein 1 Homolog antibodyAnti-Strabismus 1 antibodyAnti-Van Gogh-Like Protein 2 antibodyAnti-VANGL2 antibodyAnti-KIAA1215 antibodyAnti-STB1 antibody |
Information sourced from Uniprot.org