Anti-USP6 antibody (STJ191582)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin carboxyl-terminal hydrolase 6 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP6 |
| Gene ID | 9098 |
| Uniprot ID | UBP6_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | UBP6 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Monubiquitinated.ubiquitination is calmodulin and calcium dependent. |
| Function | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. May act as a GTPase-activating protein for RAB3A. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 6Deubiquitinating Enzyme 6Proto-Oncogene Tre-2Rn-TreUbiquitin Thioesterase 6Ubiquitin-Specific-Processing Protease 6 |
| Database Links | |
| Cellular Localisation | Cell MembraneCytoplasmEndosomeLocalizes To The Plasma Membrane And To Filamentous Structures Within The Cell Corresponding To Arf6 Regulated Tubular EndosomesActivation Of Rac1 And Cdc42 Can Direct The Relocalization Of Usp6 To The Plasma Membrane In A Manner That Depends On The Integrity Of The Actin Cytoskeleton |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 6 antibodyAnti-Deubiquitinating Enzyme 6 antibodyAnti-Proto-Oncogene Tre-2 antibodyAnti-Rn-Tre antibodyAnti-Ubiquitin Thioesterase 6 antibodyAnti-Ubiquitin-Specific-Processing Protease 6 antibodyAnti-USP6 antibodyAnti-HRP1 antibodyAnti-TRE2 antibody |
Information sourced from Uniprot.org