Anti-USP48 antibody (631-680 aa) (STJ96208)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human USP48 at the amino acid range 631-680
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin carboxyl-terminal hydrolase 48 (631-680 aa) for use in IHC, IF, WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP48 |
| Gene ID | 84196 |
| Uniprot ID | UBP48_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human USP48 at the amino acid range 631-680 |
| Immunogen Region | 631-680 aa |
| Specificity | USP48 Polyclonal Antibody detects endogenous levels of USP48 protein. |
Additional Info
| Function | Deubiquitinase that recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of polyubiquitin precursors as well as that of ubiquitinated proteins. Plays a role in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at postsynaptic sites. Plays an important role in cell cycle progression by deubiquitinating Aurora B/AURKB and thereby extending its stability. In the context of H.pylori infection, stabilizes nuclear RELA through deubiquitination, thereby promoting the transcriptional activity of RELA to prolong TNFAIP3 de novo synthesis. Consequently, TNFAIP3 suppresses caspase activity and apoptotic cell death. Also functions in the modulation of the ciliary and synaptic transport as well as cytoskeleton organization, which are key for photoreceptor function and homeostasis. To achieve this, stabilizes the levels of the retinal degeneration-associated proteins ARL3 and UNC119 using distinct mechanisms. Plays a positive role in pyroptosis by stabilizing gasdermin E/GSDME through removal of its 'Lys-48'-linked ubiquitination. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 48Deubiquitinating Enzyme 48Ubiquitin Thioesterase 48Ubiquitin-Specific Peptidase 48Ubiquitin-Specific Protease 48Ubiquitin-Specific-Processing Protease 48 |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | CytoplasmNucleusCell ProjectionCilium |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 48 antibodyAnti-Deubiquitinating Enzyme 48 antibodyAnti-Ubiquitin Thioesterase 48 antibodyAnti-Ubiquitin-Specific Peptidase 48 antibodyAnti-Ubiquitin-Specific Protease 48 antibodyAnti-Ubiquitin-Specific-Processing Protease 48 antibodyAnti-USP48 antibodyAnti-USP31 antibody |
Information sourced from Uniprot.org