Anti-USP35 antibody (STJ191577)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin carboxyl-terminal hydrolase 35 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP35 |
| Gene ID | 57558 |
| Uniprot ID | UBP35_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | UBP35 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Ubiquitinated by CHIP/STUB1 in an HSP90-dependent manner.leading to proteasomal degradation. This ubiquitination can be reversed through auto-deubiquitinating activity. |
| Function | Deubiquitinase that plays a role in different processes including cell cycle regulation, mitophagy or endoplasmic reticulum stress. Inhibits TNFalpha-induced NF-kappa-B activation through stabilizing TNIP2 protein via deubiquitination. Plays an essential role during mitosis by deubiquitinating and thereby regulating the levels of Aurora B/AURKB protein. In addition, regulates the protein levels of other key component of the chromosomal passenger complex (CPC) such as survivin/BIRC5 or Borealin/CDCA8 by enhancing their stability. Regulates the degradation of mitochondria through the process of autophagy termed mitophagy. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 35Deubiquitinating Enzyme 35Ubiquitin Thioesterase 35Ubiquitin-Specific-Processing Protease 35 |
| Database Links | |
| Cellular Localisation | CytoplasmMitochondrionOnly Associates With Polarized MitochondriaAnd Rapidly Translocates To The Cytosol During Mitophagy |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 35 antibodyAnti-Deubiquitinating Enzyme 35 antibodyAnti-Ubiquitin Thioesterase 35 antibodyAnti-Ubiquitin-Specific-Processing Protease 35 antibodyAnti-USP35 antibodyAnti-KIAA1372 antibodyAnti-USP34 antibody |
Information sourced from Uniprot.org