Anti-USP34 antibody (STJ191576)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Ubiquitin carboxyl-terminal hydrolase 34 for use in IHC and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | USP34 |
| Gene ID | 9736 |
| Uniprot ID | UBP34_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | UBP34 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 34Deubiquitinating Enzyme 34Ubiquitin Thioesterase 34Ubiquitin-Specific-Processing Protease 34 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-5689880 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 34 antibodyAnti-Deubiquitinating Enzyme 34 antibodyAnti-Ubiquitin Thioesterase 34 antibodyAnti-Ubiquitin-Specific-Processing Protease 34 antibodyAnti-USP34 antibodyAnti-KIAA0570 antibodyAnti-KIAA0729 antibody |
Information sourced from Uniprot.org