| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
USP34 |
| Gene ID: |
9736 |
| Uniprot ID: |
UBP34_HUMAN |
| Immunogen Region: |
3307-3546 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 3307-3546 of human USP34 (NP_055524.3). |
| Immunogen Sequence: |
QLNPALIPTLQELLSKCRTC LQQRNSLQEQEAKERKTKDD EGATPIKRRRVSSDEEHTVD SCISDMKTETREVLTPTSTS DNETRDSSIIDPGTEQDLPS PENSSVKEYRMEVPSSFSED MSNIRSQHAEEQSNNGRYDD CKEFKDLHCSKDSTLAEEES EFPSTSISAVLSDLADLRSC DGQALPSQDPEVALSLSCGH SRGLFSHMQQHDILDTLCRT IESTIHVVTRISGKGNQAA |
| Tissue Specificity | Expressed in brain at low level. |
| Function | Ubiquitin hydrolase that can remove conjugated ubiquitin from AXIN1 and AXIN2, thereby acting as a regulator of Wnt signaling pathway. Acts as an activator of the Wnt signaling pathway downstream of the beta-catenin destruction complex by deubiquitinating and stabilizing AXIN1 and AXIN2, leading to promote nuclear accumulation of AXIN1 and AXIN2 and positively regulate beta-catenin (CTNBB1)-mediated transcription. Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 34Deubiquitinating Enzyme 34Ubiquitin Thioesterase 34Ubiquitin-Specific-Processing Protease 34 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-5689880 |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 34 antibodyAnti-Deubiquitinating Enzyme 34 antibodyAnti-Ubiquitin Thioesterase 34 antibodyAnti-Ubiquitin-Specific-Processing Protease 34 antibodyAnti-USP34 antibodyAnti-KIAA0570 antibodyAnti-KIAA0729 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
