| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-USP22 (50-150) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
USP22 |
| Gene ID: |
23326 |
| Uniprot ID: |
UBP22_HUMAN |
| Immunogen Region: |
50-150 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human USP22 (NP_056091.1). |
| Immunogen Sequence: |
TAEARKRKAKSCICHVCGVH LNRLHSCLYCVFFGCFTKKH IHEHAKAKRHNLAIDLMYGG IYCFLCQDYIYDKDMEIIAK EEQRKAWKMQGVGEKFSTWE P |
| Tissue Specificity | Moderately expressed in various tissues including heart and skeletal muscle, and weakly expressed in lung and liver. |
| Function | Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 22Deubiquitinating Enzyme 22Ubiquitin Thioesterase 22Ubiquitin-Specific-Processing Protease 22 |
| Database Links | Reactome: R-HSA-3214847Reactome: R-HSA-5689880 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 22 antibodyAnti-Deubiquitinating Enzyme 22 antibodyAnti-Ubiquitin Thioesterase 22 antibodyAnti-Ubiquitin-Specific-Processing Protease 22 antibodyAnti-USP22 antibodyAnti-KIAA1063 antibodyAnti-USP3L antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
