Anti-USP11 antibody [R08-2D7] (STJA0033889)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human USP11
General Information
| Short Description | Rabbit monoclonal anti-USP11 for use in WB and IP in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R08-2D7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | USP11Uniprot ID=UBP11_HUMAN" |
| Immunogen | A synthetic peptide of human USP11 |
Additional Info
| Function | Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains. Inhibits the degradation of target proteins by the proteasome. Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro). Plays a role in the regulation of pathways leading to NF-kappa-B activation. Plays a role in the regulation of DNA repair after double-stranded DNA breaks. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex.may act by deubiquitinating components of the PRC1-like complex. Promotes cell proliferation by deubiquitinating phosphorylated E2F1. |
| Protein Name | Ubiquitin Carboxyl-Terminal Hydrolase 11Deubiquitinating Enzyme 11Ubiquitin Thioesterase 11Ubiquitin-Specific-Processing Protease 11 |
| Cellular Localisation | NucleusCytoplasmChromosomePredominantly NuclearAssociates With Chromatin |
| Alternative Antibody Names | Anti-Ubiquitin Carboxyl-Terminal Hydrolase 11 antibodyAnti-Deubiquitinating Enzyme 11 antibodyAnti-Ubiquitin Thioesterase 11 antibodyAnti-Ubiquitin-Specific-Processing Protease 11 antibodyAnti-USP11 antibodyAnti-UHX1 antibody |
Information sourced from Uniprot.org