| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UQCRC1 (156-480) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UQCRC1 |
| Gene ID: |
7384 |
| Uniprot ID: |
QCR1_HUMAN |
| Immunogen Region: |
156-480 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 156-480 of human UQCRC1 (NP_003356.2). |
| Immunogen Sequence: |
LEDSQIEKERDVILREMQEN DASMRDVVFNYLHATAFQGT PLAQAVEGPSENVRKLSRAD LTEYLSTHYKAPRMVLAAAG GVEHQQLLDLAQKHLGGIPW TYAEDAVPTLTPCRFTGSEI RHRDDALPFAHVAIAVEGPG WASPDNVALQVANAIIGHYD CTYGGGVHLSSPLASGAVAN KLCQSFQTFSICYAETGLLG AHFVCDRMKIDDMMFVLQGQ WMRLCTSATESEVARGKNI |
| Tissue Specificity | Expressed in brain, including substantia nigra, striatum, cortex and cerebellum, and in spinal cord, heart, kidney, liver and muscle. |
| Function | Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The 2 core subunits UQCRC1/QCR1 and UQCRC2/QCR2 are homologous to the 2 mitochondrial-processing peptidase (MPP) subunits beta-MPP and alpha-MPP respectively, and they seem to have preserved their MPP processing properties. May be involved in the in situ processing of UQCRFS1 into the mature Rieske protein and its mitochondrial targeting sequence (MTS)/subunit 9 when incorporated into complex III (Probable). Seems to play an important role in the maintenance of proper mitochondrial function in nigral dopaminergic neurons. |
| Protein Name | Cytochrome B-C1 Complex Subunit 1 - MitochondrialComplex Iii Subunit 1Core Protein IUbiquinol-Cytochrome-C Reductase Complex Core Protein 1 |
| Database Links | Reactome: R-HSA-611105 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinMatrix Side |
| Alternative Antibody Names | Anti-Cytochrome B-C1 Complex Subunit 1 - Mitochondrial antibodyAnti-Complex Iii Subunit 1 antibodyAnti-Core Protein I antibodyAnti-Ubiquinol-Cytochrome-C Reductase Complex Core Protein 1 antibodyAnti-UQCRC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
