| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Protein unc-93 homolog B1 (347-397 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UNC93B1 |
| Gene ID: | 81622 |
| Uniprot ID: | UN93B_HUMAN |
| Immunogen Region: | 347-397 aa |
| Specificity: | This antibody detects endogenous levels of UN93B at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human UN93B at the amino acid range 347-397 |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Protein Name | Protein Unc-93 Homolog B1Unc-93b1Hunc93b1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-5602415 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg DinucleotidesColocalizes With Lamp5 In Large Endosomal Intracellular Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-93 Homolog B1 antibodyAnti-Unc-93b1 antibodyAnti-Hunc93b1 antibodyAnti-UNC93B1 antibodyAnti-UNC93 antibodyAnti-UNC93B antibody |
Information sourced from Uniprot.org
