Anti-UNC93B1 antibody (347-397 aa) (STJ194377)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human UN93B at the amino acid range 347-397
General Information
| Short Description | Rabbit polyclonal anti-Protein unc-93 homolog B1 (347-397 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UNC93B1 |
| Gene ID | 81622 |
| Uniprot ID | UN93B_HUMAN |
| Immunogen | Synthesized peptide derived from the human UN93B at the amino acid range 347-397 |
| Immunogen Region | 347-397 aa |
| Specificity | This antibody detects endogenous levels of UN93B at Human/Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Protein Name | Protein Unc-93 Homolog B1Unc-93b1Hunc93b1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-5602415 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg DinucleotidesColocalizes With Lamp5 In Large Endosomal Intracellular Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-93 Homolog B1 antibodyAnti-Unc-93b1 antibodyAnti-Hunc93b1 antibodyAnti-UNC93B1 antibodyAnti-UNC93 antibodyAnti-UNC93B antibody |
Information sourced from Uniprot.org