| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Protein unc-93 homolog B1 (347-397 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UNC93B1 |
| Gene ID: |
81622 |
| Uniprot ID: |
UN93B_HUMAN |
| Immunogen Region: |
347-397 aa |
| Specificity: |
This antibody detects endogenous levels of UN93B at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human UN93B at the amino acid range 347-397 |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. |
| Protein Name | Protein Unc-93 Homolog B1Unc-93b1Hunc93b1 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-5602415 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Cell-Stimulation With Cpg DinucleotidesColocalizes With Lamp5 In Large Endosomal Intracellular Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-93 Homolog B1 antibodyAnti-Unc-93b1 antibodyAnti-Hunc93b1 antibodyAnti-UNC93B1 antibodyAnti-UNC93 antibodyAnti-UNC93B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
