| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UNC5C (300-360) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UNC5C |
| Gene ID: |
8633 |
| Uniprot ID: |
UNC5C_HUMAN |
| Immunogen Region: |
300-360 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 300-360 of human UNC5C (NP_003719.3). |
| Immunogen Sequence: |
EGQSVQKIACTTLCPVDGRW TPWSKWSTCGTECTHWRRRE CTAPAPKNGGKDCDGLVLQS K |
| Tissue Specificity | Mainly expressed in brain. Expressed in temporal lobe cortical neurons and in neurons of the hippocampal pyramidal layer. Also expressed in kidney. Not expressed in developing or adult lung. |
| Post Translational Modifications | Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Phosphorylated on different cytoplasmic tyrosine residues. Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation. Tyrosine phosphorylation is netrin-dependent. |
| Function | Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion. Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC. Also involved in corticospinal tract axon guidance independently of DCC. Involved in dorsal root ganglion axon projection towards the spinal cord. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. |
| Protein Name | Netrin Receptor Unc5cProtein Unc-5 Homolog 3Protein Unc-5 Homolog C |
| Database Links | Reactome: R-HSA-418886 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell SurfaceSynapseSynaptosomeCell ProjectionAxonDendriteGrowth ConeLamellipodiumFilopodium |
| Alternative Antibody Names | Anti-Netrin Receptor Unc5c antibodyAnti-Protein Unc-5 Homolog 3 antibodyAnti-Protein Unc-5 Homolog C antibodyAnti-UNC5C antibodyAnti-UNC5H3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
