Anti-UNC13D antibody (891-1090) (STJ115107)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UNC13D (891-1090) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UNC13D |
| Gene ID | 201294 |
| Uniprot ID | UN13D_HUMAN |
| Immunogen Region | 891-1090 |
| Immunogen Sequence | LIRKYFCSRIQQQAETTSEE LGAVTVKASYRASEQKLRVE LLSASSLLPLDSNGSSDPFV QLTLEPRHEFPELAARETQK HKKDLHPLFDETFEFLVPAE PCRKAGACLLLTVLDYDTLG ADDLEGEAFLPLREVPGLSG SEEPGEVPQTRLPLTYPAPN GDPILQLLEGRKGDREAQVF VRLRRHRAKQASQHALRPAP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 891-1090 of human UNC13D (NP_954712.1). |
Additional Info
| Tissue Specificity | Expressed at high levels in spleen, thymus and leukocytes. Also expressed in lung and placenta, and at very low levels in brain, heart, skeletal muscle and kidney. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. |
| Function | Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells. |
| Protein Name | Protein Unc-13 Homolog DMunc13-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinLate EndosomeRecycling EndosomeLysosomeColocalizes With Cytotoxic Granules At The Plasma MembraneLocalizes To Endosomal Exocytic Vesicles |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog D antibodyAnti-Munc13-4 antibodyAnti-UNC13D antibody |
Information sourced from Uniprot.org