| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Protein unc-13 homolog B (1325-1375 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UNC13B |
| Gene ID: | 10497 |
| Uniprot ID: | UN13B_HUMAN |
| Immunogen Region: | 1325-1375 aa |
| Specificity: | This antibody detects endogenous levels of UN13B at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human UN13B at the amino acid range 1325-1375 |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. In collaboration with UNC13A, facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. |
| Protein Name | Protein Unc-13 Homolog BMunc13-2Munc13 |
| Database Links | Reactome: R-HSA-181429Reactome: R-HSA-181430Reactome: R-HSA-210500Reactome: R-HSA-212676Reactome: R-HSA-264642 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCell MembraneSynapseLocalized To SynapsesTranslocated To The Plasma Membrane In Response To Phorbol Ester Binding |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog B antibodyAnti-Munc13-2 antibodyAnti-Munc13 antibodyAnti-UNC13B antibodyAnti-UNC13 antibody |
Information sourced from Uniprot.org
