| Tissue Specificity | Expressed in pancreatic islet cells. Expressed in melanocytes. |
| Function | Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Facilitates neuronal dense core vesicles fusion as well as controls the location and efficiency of their synaptic release. Also involved in secretory granule priming in insulin secretion. Plays a role in dendrite formation by melanocytes. |
| Protein Name | Protein Unc-13 Homolog AMunc13-1 |
| Database Links | |
| Cellular Localisation | CytoplasmCell MembranePeripheral Membrane ProteinPresynaptic Cell MembranePresynaptic Active ZoneTranslocated To The Plasma Membrane In Response To Phorbol Ester Binding |
| Alternative Antibody Names | Anti-Protein Unc-13 Homolog A antibodyAnti-Munc13-1 antibodyAnti-UNC13A antibodyAnti-KIAA1032 antibody |
Information sourced from Uniprot.org
