Anti-ULK3 antibody (452-472) {FITC} (STJ503469)

SKU:
STJ503469-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Bovine/Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ULK3 (452-472) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.65 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Ulk3
Gene ID: 691171
Uniprot ID: ULK3_RAT
Immunogen Region: 452-472
Immunogen: Synthetic peptide corresponding to a region within C terminal amino acids 452-472 of Mouse ULK3, coupled to a carrier protein.
Post Translational Modifications Autophosphorylated. Autophosphorylation is blocked by interaction with SUFU.
Function Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
Protein Name Serine/Threonine-Protein Kinase Ulk3
Unc-51-Like Kinase 3
Database Links Reactome: R-RNO-5632684
Cellular Localisation Cytoplasm
Localizes To Pre-Autophagosomal Structure During Cellular Senescence
Alternative Antibody Names Anti-Serine/Threonine-Protein Kinase Ulk3 antibody
Anti-Unc-51-Like Kinase 3 antibody
Anti-Ulk3 antibody

Information sourced from Uniprot.org

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