| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-UGT2B7 (25-351) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UGT2B7 |
| Gene ID: |
7364 |
| Uniprot ID: |
UD2B7_HUMAN |
| Immunogen Region: |
25-351 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 25-351 of human UGT2B7 (NP_001065.2). |
| Immunogen Sequence: |
KVLVWAAEYSHWMNIKTILD ELIQRGHEVTVLASSASILF DPNNSSALKIEIYPTSLTKT ELENFIMQQIKRWSDLPKDT FWLYFSQVQEIMSIFGDITR KFCKDVVSNKKFMKKVQESR FDVIFADAIFPCSELLAELF NIPFVYSLSFSPGYTFEKHS GGFIFPPSYVPVVMSELTDQ MTFMERVKNMIYVLYFDFWF EIFDMKKWDQFYSEVLGRPT TLSETMGKADVWLIRNSWN |
| Function | UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol, catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent. |
| Protein Name | Udp-Glucuronosyltransferase 2b7Udpgt 2b7Ugt2b73 -4-Catechol Estrogen-Specific UdpgtUdp-Glucuronosyltransferase 2b9Udpgt 2b9Udpgth-2 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-9749641Reactome: R-HSA-9757110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 2b7 antibodyAnti-Udpgt 2b7 antibodyAnti-Ugt2b7 antibodyAnti-3 -4-Catechol Estrogen-Specific Udpgt antibodyAnti-Udp-Glucuronosyltransferase 2b9 antibodyAnti-Udpgt 2b9 antibodyAnti-Udpgth-2 antibodyAnti-UGT2B7 antibodyAnti-UGTB2B9 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
