Anti-UGT1A9 antibody (26-250) (STJ26037)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal UGT1A9 (26-250) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UGT1A9 |
| Gene ID | 54600 |
| Uniprot ID | UD19_HUMAN |
| Immunogen Region | 26-250 |
| Immunogen Sequence | GKLLVVPMDGSHWFTMRSVV EKLILRGHEVVVVMPEVSWQ LGRSLNCTVKTYSTSYTLED LDREFKAFAHAQWKAQVRSI YSLLMGSYNDIFDLFFSNCR SLFKDKKLVEYLKESSFDAV FLDPFDNCGLIVAKYFSLPS VVFARGILCHYLEEGAQCPA PLSYVPRILLGFSDAMTFKE RVRNHIMHLEEHLLCHRFFK NALEIASEILQTPVTEYDLY SHTSI |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 26-250 of human UGT1A9 (NP_066307.1). |
Additional Info
| Tissue Specificity | Isoform 1: Expressed in liver, kidney, colon, esophagus and small intestine. Isoform 2: Expressed in liver, kidney, colon, esophagus and small intestine. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol and estrone. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, PGB1 and F2-isoprostanes (8-iso-PGF2alpha and 5-epi-5-F2t-IsoP). Glucuronates the phytochemical ferulic acid efficently at both the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Also metabolizes mycophenolate, an immunosuppressive agent. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a9Ugt1a9Udp-Glucuronosyltransferase 1-9Udpgt 1-9Ugt1*9Ugt1-09Ugt1.9Udp-Glucuronosyltransferase 1-IUgt-1iUgt1iLugp4 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-1989781Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a9 antibodyAnti-Ugt1a9 antibodyAnti-Udp-Glucuronosyltransferase 1-9 antibodyAnti-Udpgt 1-9 antibodyAnti-Ugt1*9 antibodyAnti-Ugt1-09 antibodyAnti-Ugt1.9 antibodyAnti-Udp-Glucuronosyltransferase 1-I antibodyAnti-Ugt-1i antibodyAnti-Ugt1i antibodyAnti-Lugp4 antibodyAnti-UGT1A9 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org