Anti-UGT1A5 antibody (88-138 aa) (STJ194184)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human UD15 at the amino acid range 88-138
General Information
| Short Description | Rabbit polyclonal anti-UDP-glucuronosyltransferase 1A5 (88-138 aa) for use in WB in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UGT1A5 |
| Gene ID | 54579 |
| Uniprot ID | UD15_HUMAN |
| Immunogen | Synthesized peptide derived from the human UD15 at the amino acid range 88-138 |
| Immunogen Region | 88-138 aa |
| Specificity | This antibody detects endogenous levels of UD15 at Human/Rat |
Additional Info
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist zolarsatan, a drug which can inhibit the effect of angiotensin II. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a5Ugt1a5Udp-Glucuronosyltransferase 1-5Udpgt 1-5Ugt1*5Ugt1-05Ugt1.5Udp-Glucuronosyltransferase 1-EUgt-1eUgt1e |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-9749641 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a5 antibodyAnti-Ugt1a5 antibodyAnti-Udp-Glucuronosyltransferase 1-5 antibodyAnti-Udpgt 1-5 antibodyAnti-Ugt1*5 antibodyAnti-Ugt1-05 antibodyAnti-Ugt1.5 antibodyAnti-Udp-Glucuronosyltransferase 1-E antibodyAnti-Ugt-1e antibodyAnti-Ugt1e antibodyAnti-UGT1A5 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org