Anti-UGT1A1 antibody (101-200) [S4891RM] (STJ11104891)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Udp-Glucuronosyltransferase 1a1 (101-200) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4891RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UGT1A1 |
| Gene ID | 54658 |
| Uniprot ID | UD11_HUMAN |
| Immunogen Region | 101-200 |
| Immunogen Sequence | ENDSFLQRVIKTYKKIKKDS AMLLSGCSHLLHNKELMASL AESSFDVMLTDPFLPCSPIV AQYLSLPTVFFLHALPCSLE FEATQCPNPFSYVPRPLSSH |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human UGT1A1 (NP_000454.1). |
Additional Info
| Tissue Specificity | Isoform 1: Expressed in liver, colon and small intestine. Not expressed in kidney, esophagus and skin. Isoform 2: Expressed in liver, colon, small intestine and kidney. Not expressed in esophagus and skin. |
| Function | Isoform 1: UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous estrogen hormones such as estradiol, estrone and estriol. Involved in the glucuronidation of bilirubin, a degradation product occurring in the normal catabolic pathway that breaks down heme in vertebrates. Involved in the glucuronidation of arachidonic acid (AA) and AA-derived eicosanoids including 15-HETE, 20-HETE, PGB1 and F2-isoprostane (8-iso-PGF2alpha). Involved in the glucuronidation of the phytochemical ferulic acid at the phenolic or the carboxylic acid group. Also catalyzes the glucuronidation the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, a drug which can inhibit the effect of angiotensin II. Involved in the biotransformation of 7-ethyl-10-hydroxycamptothecin (SN-38), the pharmacologically active metabolite of the anticancer drug irinotecan. Isoform 2: Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1. |
| Protein Name | Udp-Glucuronosyltransferase 1a1Ugt1a1Bilirubin-Specific Udpgt Isozyme 1Hug-Br1Udp-Glucuronosyltransferase 1-1Udpgt 1-1Ugt1*1Ugt1-01Ugt1.1Udp-Glucuronosyltransferase 1a Isoform 1 |
| Database Links | Reactome: R-HSA-156588Reactome: R-HSA-189483Reactome: R-HSA-5579002Reactome: R-HSA-9749641Reactome: R-HSA-9753281 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Udp-Glucuronosyltransferase 1a1 antibodyAnti-Ugt1a1 antibodyAnti-Bilirubin-Specific Udpgt Isozyme 1 antibodyAnti-Hug-Br1 antibodyAnti-Udp-Glucuronosyltransferase 1-1 antibodyAnti-Udpgt 1-1 antibodyAnti-Ugt1*1 antibodyAnti-Ugt1-01 antibodyAnti-Ugt1.1 antibodyAnti-Udp-Glucuronosyltransferase 1a Isoform 1 antibodyAnti-UGT1A1 antibodyAnti-GNT1 antibodyAnti-UGT1 antibody |
Information sourced from Uniprot.org