| Tissue Specificity | Expressed in numerous cells of the smell, touch, vision, hearing and taste senses. Expressed in cells of the olfactory pathway, including the olfactory cell layer of the main olfactory epithelium (MOE), a mitral neuron cell layer of the olfactory bulb (OB), and a pyramidal cell layer of the piriform cortex of the olfactory cortex (OC). Expressed in the vomeronasal sensory epithelium of the vomeronasal organ (VNO) and the mitral cells of the accessory olfactory bulb. Expressed in tactile tissues, including the dorsal root ganglion, trigeminal ganglion and follicle-sinus complexes. Expressed in cells between hair follicle and sinus and also in the region of the rete ridge collar. Expressed in taste buds of the fungiform, circumvallate, and foliate papillae. Expressed in the spiral ganglion, the organ of Corti of the cochlea in the inner ear, in the sensory epithelium of macula and vestibular ganglion of the balancing system (at protein level). Expressed in the liver and skeletal muscle. |
| Function | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Does not bind to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. May play a role in Shh signaling by mediating the ubiquitination of Kif7. May be important for MYH9 function in certain tissues, possibly by regulating the ubiquitination of MYH9 and consequently affecting its interaction with MYO7A. |
| Protein Name | E3 Ubiquitin-Protein Ligase Ubr3N-Recognin-3Ring-Type E3 Ubiquitin Transferase Ubr3Ubiquitin-Protein Ligase E3-Alpha-3Ubiquitin-Protein Ligase E3-Alpha-IiiZinc Finger Protein 650 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Ubr3 antibodyAnti-N-Recognin-3 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Ubr3 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-3 antibodyAnti-Ubiquitin-Protein Ligase E3-Alpha-Iii antibodyAnti-Zinc Finger Protein 650 antibodyAnti-Ubr3 antibodyAnti-Kiaa2024 antibodyAnti-Zfp650 antibodyAnti-Znf650 antibody |
Information sourced from Uniprot.org
