Anti-UBN1 antibody (161-210 aa) (STJ96171)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Ubinuclein at the amino acid range 161-210
General Information
| Short Description | Rabbit polyclonal anti-Ubinuclein-1 (161-210 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | UBN1 |
| Gene ID | 29855 |
| Uniprot ID | UBN1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Ubinuclein at the amino acid range 161-210 |
| Immunogen Region | 161-210 aa |
| Specificity | UBN-1 Polyclonal Antibody detects endogenous levels of UBN-1 protein. |
Additional Info
| Function | Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly. |
| Protein Name | Ubinuclein-1Hira-Binding ProteinProtein Vt4Ubiquitously Expressed Nuclear Protein |
| Database Links | Reactome: R-HSA-2559584 |
| Cellular Localisation | NucleusNucleoplasmPml BodyCell JunctionTight JunctionLocalized As A Nuclear Speckled-Like Pattern In Proliferating Primary FibroblastsColocalizes With HiraPml And Sp100 In Pml Bodies Of Senescent CellsColocalizes With Tjp1 And Cldn1Detected Along The Upper Granular Cell Layer Of EpidermisWhen OverexpressedAccumulates In The Nucleus In Cells Showing Defective Cytokinesis |
| Alternative Antibody Names | Anti-Ubinuclein-1 antibodyAnti-Hira-Binding Protein antibodyAnti-Protein Vt4 antibodyAnti-Ubiquitously Expressed Nuclear Protein antibodyAnti-UBN1 antibody |
Information sourced from Uniprot.org