• Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using Ubinuclein Antibody. The picture on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of A549 cells, using Ubinuclein Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-UBN1 antibody (161-210 aa) (STJ96171)

SKU:
STJ96171

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Ubinuclein-1 (161-210 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBN1
Gene ID: 29855
Uniprot ID: UBN1_HUMAN
Immunogen Region: 161-210 aa
Specificity: UBN-1 Polyclonal Antibody detects endogenous levels of UBN-1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Ubinuclein at the amino acid range 161-210
Function Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.
Protein Name Ubinuclein-1
Hira-Binding Protein
Protein Vt4
Ubiquitously Expressed Nuclear Protein
Database Links Reactome: R-HSA-2559584
Cellular Localisation Nucleus
Nucleoplasm
Pml Body
Cell Junction
Tight Junction
Localized As A Nuclear Speckled-Like Pattern In Proliferating Primary Fibroblasts
Colocalizes With Hira
Pml And Sp100 In Pml Bodies Of Senescent Cells
Colocalizes With Tjp1 And Cldn1
Detected Along The Upper Granular Cell Layer Of Epidermis
When Overexpressed
Accumulates In The Nucleus In Cells Showing Defective Cytokinesis
Alternative Antibody Names Anti-Ubinuclein-1 antibody
Anti-Hira-Binding Protein antibody
Anti-Protein Vt4 antibody
Anti-Ubiquitously Expressed Nuclear Protein antibody
Anti-UBN1 antibody

Information sourced from Uniprot.org

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