Anti-UBIAD1 antibody (1-100) (STJ116146)

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STJ116146
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Host: Rabbit
Applications: WB/IHC-P/IF/ICC/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
IHC-P:1:100-1:500
IF/ICC:1:50-1:200
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: UBIAD1
Gene ID: 29914
Uniprot ID: UBIA1_HUMAN
Immunogen Region: 1-100
Specificity: A synthetic peptide corresponding to a sequence within amino acids 1-100 of human UBIAD1 (NP_037451.1).
Immunogen Sequence: MAASQVLGEKINILSGETVK AGDRDPLGNDCPEQDRLPQR SWRQKCASYVLALRPWSFSA SLTPVALGSALAYRSHGVLD PRLLVGCAVAVLAVHGAGNL
Tissue Specificity Ubiquitously expressed.
Function Prenyltransferase that mediates the formation of menaquinone-4 (MK-4) and coenzyme Q10. MK-4 is a vitamin K2 isoform present at high concentrations in the brain, kidney and pancreas, and is required for endothelial cell development. Mediates the conversion of phylloquinone (PK) into MK-4, probably by cleaving the side chain of phylloquinone (PK) to release 2-methyl-1,4-naphthoquinone (menadione.K3) and then prenylating it with geranylgeranyl pyrophosphate (GGPP) to form MK-4. Also plays a role in cardiovascular development independently of MK-4 biosynthesis, by acting as a coenzyme Q10 biosynthetic enzyme: coenzyme Q10, also named ubiquinone, plays an important antioxidant role in the cardiovascular system. Mediates biosynthesis of coenzyme Q10 in the Golgi membrane, leading to protect cardiovascular tissues from NOS3/eNOS-dependent oxidative stress.
Protein Name Ubia Prenyltransferase Domain-Containing Protein 1
Transitional Epithelial Response Protein 1
Database Links Reactome: R-HSA-6806664
Cellular Localisation Endoplasmic Reticulum Membrane
Multi-Pass Membrane Protein
Golgi Apparatus Membrane
Mitochondrion Membrane
Cytoplasm
Nucleus
Alternative Antibody Names Anti-Ubia Prenyltransferase Domain-Containing Protein 1 antibody
Anti-Transitional Epithelial Response Protein 1 antibody
Anti-UBIAD1 antibody
Anti-TERE1 antibody

Information sourced from Uniprot.org