| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Ubiquitin-protein ligase E3B (581-630 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE3B |
| Gene ID: | 89910 |
| Uniprot ID: | UBE3B_HUMAN |
| Immunogen Region: | 581-630 aa |
| Specificity: | UBE3B Polyclonal Antibody detects endogenous levels of UBE3B protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human UBE3B at the amino acid range 581-630 |
| Function | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Ubiquitinates BCKDK and targets it for degradation, thereby regulating various metabolic processes. Involved in the positive regulation of neurite branching in hippocampal neurons and the control of neuronal spine number and morphology, through the ubiquitination of PPP3CC. |
| Protein Name | Ubiquitin-Protein Ligase E3bHect-Type Ubiquitin Transferase E3b |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Postsynaptic Density |
| Alternative Antibody Names | Anti-Ubiquitin-Protein Ligase E3b antibodyAnti-Hect-Type Ubiquitin Transferase E3b antibodyAnti-UBE3B antibody |
Information sourced from Uniprot.org