| Tissue Specificity | Widely expressed, with highest expression in brain, liver, pancreas and heart. |
| Post Translational Modifications | Autoubiquitinated at Met-1. |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Specifically monoubiquitinates the N-terminus of various substrates, including ATXN3, MAPT/TAU, POLR2H/RPB8 and STUB1/CHIP, by recognizing backbone atoms of disordered N-termini. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. UBE2W-catalyzed ubiquitination occurs also in the presence of inactive RING/U-box type E3s, i.e. lacking the active site cysteine residues to form thioester bonds with ubiquitin, or even in the absence of E3, albeit at a slower rate. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 WE2 Ubiquitin-Conjugating Enzyme WN-Terminal E2 Ubiquitin-Conjugating EnzymeN-Terminus-Conjugating E2Ubiquitin Carrier Protein WUbiquitin-Conjugating Enzyme 16Ubc-16Ubiquitin-Protein Ligase W |
| Database Links | Reactome: R-HSA-8866652Reactome: R-HSA-983168 |
| Cellular Localisation | NucleusIn The NucleusColocalizes With Fancl |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 W antibodyAnti-E2 Ubiquitin-Conjugating Enzyme W antibodyAnti-N-Terminal E2 Ubiquitin-Conjugating Enzyme antibodyAnti-N-Terminus-Conjugating E2 antibodyAnti-Ubiquitin Carrier Protein W antibodyAnti-Ubiquitin-Conjugating Enzyme 16 antibodyAnti-Ubc-16 antibodyAnti-Ubiquitin-Protein Ligase W antibodyAnti-UBE2W antibodyAnti-UBC16 antibody |
Information sourced from Uniprot.org
