| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-UBE2D1 (1-147) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC-P 1:50-1:200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBE2D1 |
| Gene ID: | 7321 |
| Uniprot ID: | UB2D1_HUMAN |
| Immunogen Region: | 1-147 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-147 of human UBE2D1 (NP_003329.1). |
| Immunogen Sequence: | MALKRIQKELSDLQRDPPAH CSAGPVGDDLFHWQATIMGP PDSAYQGGVFFLTVHFPTDY PFKPPKIAFTTKIYHPNINS NGSICLDILRSQWSPALTVS KVLLSICSLLCDPNPDDPLV PDIAQIYKSDKEKYNRHARE WTQKYAM |
| Tissue Specificity | Ubiquitous. Up-regulated in livers of iron-overloaded patients with hereditary hemochromatosis. |
| Post Translational Modifications | Autoubiquitinated in vitro. |
| Function | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 D1(E3-Independent E2 Ubiquitin-Conjugating Enzyme D1E2 Ubiquitin-Conjugating Enzyme D1Stimulator Of Fe TransportSftUbc4/5 HomologUbch5Ubiquitin Carrier Protein D1Ubiquitin-Conjugating Enzyme E2(17kb 1Ubiquitin-Conjugating Enzyme E2-17 Kda 1Ubiquitin-Protein Ligase D1 |
| Database Links | Reactome: R-HSA-1234176Reactome: R-HSA-141430Reactome: R-HSA-168927Reactome: R-HSA-174048Reactome: R-HSA-174084Reactome: R-HSA-174154Reactome: R-HSA-174178Reactome: R-HSA-174184Reactome: R-HSA-176407Reactome: R-HSA-176408Reactome: R-HSA-176409Reactome: R-HSA-176412Reactome: R-HSA-179409Reactome: R-HSA-201451Reactome: R-HSA-202424Reactome: R-HSA-2173795Reactome: R-HSA-2467813Reactome: R-HSA-2559582Reactome: R-HSA-2871837Reactome: R-HSA-5357905Reactome: R-HSA-5607764Reactome: R-HSA-5689896Reactome: R-HSA-68867Reactome: R-HSA-69017Reactome: R-HSA-8853884Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-8951664Reactome: R-HSA-9033241Reactome: R-HSA-936440Reactome: R-HSA-937041Reactome: R-HSA-9687136Reactome: R-HSA-9705462Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 D1 antibodyAnti-(E3-Independent E2 Ubiquitin-Conjugating Enzyme D1 antibodyAnti-E2 Ubiquitin-Conjugating Enzyme D1 antibodyAnti-Stimulator Of Fe Transport antibodyAnti-Sft antibodyAnti-Ubc4/5 Homolog antibodyAnti-Ubch5 antibodyAnti-Ubiquitin Carrier Protein D1 antibodyAnti-Ubiquitin-Conjugating Enzyme E2(17kb 1 antibodyAnti-Ubiquitin-Conjugating Enzyme E2-17 Kda 1 antibodyAnti-Ubiquitin-Protein Ligase D1 antibodyAnti-UBE2D1 antibodyAnti-SFT antibodyAnti-UBC5A antibodyAnti-UBCH5 antibodyAnti-UBCH5A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
