| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
UBE2B |
| Gene ID: |
7320 |
| Uniprot ID: |
UBE2B_HUMAN |
| Immunogen Region: |
1-152 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-152 of human UBE2B (NP_003328.1). |
| Immunogen Sequence: |
MSTPARRRLMRDFKRLQEDP PVGVSGAPSENNIMQWNAVI FGPEGTPFEDGTFKLVIEFS EEYPNKPPTVRFLSKMFHPN VYADGSICLDILQNRWSPTY DVSSILTSIQSLLDEPNPNS PANSQAAQLYQENKREYEKR VSAIVEQSWNDS |
| Function | E2 ubiquitin-conjugating enzyme that accepts ubiquitin from the ubiquitin-activating enzyme E1 and transfers it to a E3 ubiquitin-protein ligase. In vitro catalyzes 'Lys-11'-, as well as 'Lys-48'- and 'Lys-63'-linked polyubiquitination. Together with the E3 enzyme BRE1 (RNF20 and/or RNF40), plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B at 'Lys-120' to form H2BK120ub1. H2BK120ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. May play a role in DNA repair. Associates to the E3 ligase RAD18 to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. In association with the E3 enzyme UBR4, is involved in N-end rule-dependent protein degradation. May be involved in neurite outgrowth. |
| Protein Name | Ubiquitin-Conjugating Enzyme E2 BE2 Ubiquitin-Conjugating Enzyme BRad6 Homolog BHr6bHhr6bUbiquitin Carrier Protein BUbiquitin-Conjugating Enzyme E2-17 KdaUbiquitin-Protein Ligase B |
| Database Links | Reactome: R-HSA-110314Reactome: R-HSA-8866652Reactome: R-HSA-8866654Reactome: R-HSA-983168 |
| Cellular Localisation | Cell MembraneNucleusIn Peripheral NeuronsExpressed Both At The Plasma Membrane And In Nuclei |
| Alternative Antibody Names | Anti-Ubiquitin-Conjugating Enzyme E2 B antibodyAnti-E2 Ubiquitin-Conjugating Enzyme B antibodyAnti-Rad6 Homolog B antibodyAnti-Hr6b antibodyAnti-Hhr6b antibodyAnti-Ubiquitin Carrier Protein B antibodyAnti-Ubiquitin-Conjugating Enzyme E2-17 Kda antibodyAnti-Ubiquitin-Protein Ligase B antibodyAnti-UBE2B antibodyAnti-RAD6B antibodyAnti-UBCH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
