| Tissue Specificity | Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines. |
| Post Translational Modifications | ISGylated. Ubiquitinated by RNF170. |
| Function | E1-activating enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of ISG15 to additional interferon stimulated proteins (ISGs) as well as other cellular proteins such as P53 in a process termed protein ISGylation. Plays an essential role in antiviral immunity together with ISG15 by restricting the replication of many viruses including rabies virus, influenza virus, sindbis virus, rotavirus or human cytomegalovirus. For example, ISG15 modification of influenza A protein NS1 disrupts the association of the NS1 with importin-alpha leading to NS1 nuclear import inhibition. ISGylation of human cytomegalovirs protein UL26 regulates its stability and inhibits its activities to suppress NF-kappa-B signaling. |
| Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 7Ubiquitin-Activating Enzyme 7D8Ubiquitin-Activating Enzyme E1 Homolog |
| Database Links | Reactome: R-HSA-1169408Reactome: R-HSA-168928Reactome: R-HSA-5656169Reactome: R-HSA-936440Reactome: R-HSA-983168Reactome: R-HSA-9909505 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ubiquitin-Like Modifier-Activating Enzyme 7 antibodyAnti-Ubiquitin-Activating Enzyme 7 antibodyAnti-D8 antibodyAnti-Ubiquitin-Activating Enzyme E1 Homolog antibodyAnti-UBA7 antibodyAnti-UBE1L antibodyAnti-UBE2 antibody |
Information sourced from Uniprot.org
