| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | UBAP1 |
| Gene ID: | 51271 |
| Uniprot ID: | UBAP1_HUMAN |
| Immunogen Region: | 1-300 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human UBAP1 (NP_057609.2). |
| Immunogen Sequence: | MASKKLGADFHGTFSYLDDV PFKTGDKFKTPAKVGLPIGF SLPDCLQVVREVQYDFSLEK KTIEWAEEIKKIEEAEREAE CKIAEAEAKVNSKSGPEGDS KMSFSKTHSTATMPPPINPI LASLQHNSILTPTRVSSSAT KQKVLSPPHIKADFNLADFE CEEDPFDNLELKTIDEKEEL RNILVGTTGPIMAQLLDNNL PRGGSGSVLQDEEVLASLER ATLDFKPLHKPNGFITLPQ |
| Tissue Specificity | Ubiquitous. Highly expressed in heart, brain, placenta, lung, liver, skeletal muscle and pancreas. |
| Function | Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. |
| Protein Name | Ubiquitin-Associated Protein 1Ubap-1Nasopharyngeal Carcinoma-Associated Gene 20 Protein |
| Database Links | Reactome: R-HSA-162588Reactome: R-HSA-174490Reactome: R-HSA-917729Reactome: R-HSA-9610379Reactome: R-HSA-9615710 |
| Cellular Localisation | CytoplasmCytosolEndosomePredominantly CytosolicRecruited To Endosomes As Part Of The Escrt-I Complex |
| Alternative Antibody Names | Anti-Ubiquitin-Associated Protein 1 antibodyAnti-Ubap-1 antibodyAnti-Nasopharyngeal Carcinoma-Associated Gene 20 Protein antibodyAnti-UBAP1 antibodyAnti-NAG20 antibody |
Information sourced from Uniprot.org