| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SUMO-activating enzyme subunit 2 (591-640 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | UBA2 |
| Gene ID: | 10054 |
| Uniprot ID: | SAE2_HUMAN |
| Immunogen Region: | 591-640 aa |
| Specificity: | UBA2 Polyclonal Antibody detects endogenous levels of UBA2 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Uba2 at the amino acid range 591-640 |
| Function | The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. |
| Protein Name | Sumo-Activating Enzyme Subunit 2 Anthracycline-Associated Resistance Arx Ubiquitin-Like 1-Activating Enzyme E1b Ubiquitin-Like Modifier-Activating Enzyme 2 |
| Database Links | Reactome: R-HSA-3065676 Reactome: R-HSA-3065678 |
| Cellular Localisation | Cytoplasm Nucleus Shuttles Between The Cytoplasm And The Nucleus Sumoylation Is Required Either For Nuclear Translocation Or Nuclear Retention |
| Alternative Antibody Names | Anti-Sumo-Activating Enzyme Subunit 2 antibody Anti-Anthracycline-Associated Resistance Arx antibody Anti-Ubiquitin-Like 1-Activating Enzyme E1b antibody Anti-Ubiquitin-Like Modifier-Activating Enzyme 2 antibody Anti-UBA2 antibody Anti-SAE2 antibody Anti-UBLE1B antibody Anti-HRIHFB2115 antibody |
Information sourced from Uniprot.org
