Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Ubiquitin-like modifier-activating enzyme 1 (91-140 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | UBA1 |
Gene ID: | 7317 |
Uniprot ID: | UBA1_HUMAN |
Immunogen Region: | 91-140 aa |
Specificity: | UBA1 Polyclonal Antibody detects endogenous levels of UBA1 protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the N-terminal region of human UBA1 at the amino acid range 91-140 |
Post Translational Modifications | ISGylated. |
Function | Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system. Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. |
Protein Name | Ubiquitin-Like Modifier-Activating Enzyme 1Protein A1s9Ubiquitin-Activating Enzyme E1 |
Database Links | Reactome: R-HSA-8866652Reactome: R-HSA-983168 |
Cellular Localisation | CytoplasmMitochondrionNucleusIsoform 1: NucleusIsoform 2: Cytoplasm |
Alternative Antibody Names | Anti-Ubiquitin-Like Modifier-Activating Enzyme 1 antibodyAnti-Protein A1s9 antibodyAnti-Ubiquitin-Activating Enzyme E1 antibodyAnti-UBA1 antibodyAnti-A1S9T antibodyAnti-UBE1 antibody |
Information sourced from Uniprot.org