| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
TYRP1 |
| Gene ID: |
7306 |
| Uniprot ID: |
TYRP1_HUMAN |
| Immunogen Region: |
350-450 aa |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TYRP1 (NP_000541.1). |
| Immunogen Sequence: |
NSTNSFRNTVEGYSDPTGKY DPAVRSLHNLAHLFLNGTGG QTHLSPNDPIFVLLHTFTDA VFDEWLRRYNADISTFPLEN APIGHNRQYNMVPFWPPVTN T |
| Tissue Specificity | Pigment cells. |
| Post Translational Modifications | Glycosylated. |
| Function | Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6-quinone-2-carboxylic acid in the presence of bound Cu(2+) ions, but not in the presence of Zn(2+). May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. |
| Protein Name | 5 -6-Dihydroxyindole-2-Carboxylic Acid OxidaseDhica OxidaseCatalase BGlycoprotein 75Melanoma Antigen Gp75Tyrosinase-Related Protein 1TrpTrp-1Trp1 |
| Database Links | Reactome: R-HSA-5662702Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneSingle-Pass Type I Membrane ProteinLocated To Mature Stage Iii And Iv Melanosomes And Apposed Endosomal Tubular MembranesTransported To Pigmented Melanosomes By The Bloc-1 ComplexProper Trafficking To Melanosome Is Regulated By Sgsm2Ankrd27Rab9aRab32 And Rab38 |
| Alternative Antibody Names | Anti-5 -6-Dihydroxyindole-2-Carboxylic Acid Oxidase antibodyAnti-Dhica Oxidase antibodyAnti-Catalase B antibodyAnti-Glycoprotein 75 antibodyAnti-Melanoma Antigen Gp75 antibodyAnti-Tyrosinase-Related Protein 1 antibodyAnti-Trp antibodyAnti-Trp-1 antibodyAnti-Trp1 antibodyAnti-TYRP1 antibodyAnti-CAS2 antibodyAnti-TYRP antibodyAnti-TYRRP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
