Anti-TXNRD1 antibody (268-318 aa) (STJ192915)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein at the amino acid range 268-318
General Information
| Short Description | Rabbit polyclonal anti-Thioredoxin reductase 1, cytoplasmic (268-318 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TXNRD1 |
| Gene ID | 7296 |
| Uniprot ID | TRXR1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein at the amino acid range 268-318 |
| Immunogen Region | 268-318 aa |
| Specificity | TRXR1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Isoform 5: The N-terminus is blocked. ISGylated. |
| Function | Reduces disulfideprotein thioredoxin (Trx) to its dithiol-containing form. Homodimeric flavoprotein involved in the regulation of cellular redox reactions, growth and differentiation. Contains a selenocysteine residue at the C-terminal active site that is essential for catalysis (Probable). Also has reductase activity on hydrogen peroxide (H2O2). Isoform 1: Induces actin and tubulin polymerization, leading to formation of cell membrane protrusions. Isoform 4: Enhances the transcriptional activity of estrogen receptors ESR1 and ESR2. Isoform 5: Enhances the transcriptional activity of the estrogen receptor ESR2 only. Mediates cell death induced by a combination of interferon-beta and retinoic acid. |
| Protein Name | Thioredoxin Reductase 1 - CytoplasmicTrGene Associated With Retinoic And Interferon-Induced Mortality 12 ProteinGrim-12Gene Associated With Retinoic And Ifn-Induced Mortality 12 ProteinKm-102-Derived Reductase-Like FactorPeroxidase Txnrd1Thioredoxin Reductase Tr1 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2408550Reactome: R-HSA-3299685Reactome: R-HSA-499943Reactome: R-HSA-5263617Reactome: R-HSA-5336415Reactome: R-HSA-5628897Reactome: R-HSA-9818027 |
| Cellular Localisation | Isoform 1: CytoplasmIsoform 4: CytoplasmNucleusIsoform 5: Cytoplasm |
| Alternative Antibody Names | Anti-Thioredoxin Reductase 1 - Cytoplasmic antibodyAnti-Tr antibodyAnti-Gene Associated With Retinoic And Interferon-Induced Mortality 12 Protein antibodyAnti-Grim-12 antibodyAnti-Gene Associated With Retinoic And Ifn-Induced Mortality 12 Protein antibodyAnti-Km-102-Derived Reductase-Like Factor antibodyAnti-Peroxidase Txnrd1 antibodyAnti-Thioredoxin Reductase Tr1 antibodyAnti-TXNRD1 antibodyAnti-GRIM12 antibodyAnti-KDRF antibody |
Information sourced from Uniprot.org