Anti-TXNIP antibody (N-Term) (STJA0010356)

SKU:
STJA0010356

Current Stock:
Host: Rabbit
Applications: IHC/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Thioredoxin-interacting protein (N-Term) is suitable for use in Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TXNIP
Gene ID: 10628
Uniprot ID: TXNIP_HUMAN
Immunogen Region: N-Term
Specificity: This antibody detects endogenous levels of TXNIP at Human, Mouse, Rat
Immunogen: Synthesized peptide derived from human N-ternal TXNIP
Function May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
Protein Name Thioredoxin-Interacting Protein
Thioredoxin-Binding Protein 2
Vitamin D3 Up-Regulated Protein 1
Database Links Reactome: R-HSA-844456
Reactome: R-HSA-9617629
Reactome: R-HSA-9660826
Reactome: R-HSA-9707564
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Thioredoxin-Interacting Protein antibody
Anti-Thioredoxin-Binding Protein 2 antibody
Anti-Vitamin D3 Up-Regulated Protein 1 antibody
Anti-TXNIP antibody
Anti-VDUP1 antibody

Information sourced from Uniprot.org

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