| Post Translational Modifications | Phosphorylated by CK1 in the proline-rich (Pro-rich) region. |
| Function | Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation. |
| Protein Name | Speckle Targeted Pip5k1a-Regulated Poly(A PolymeraseStar-PapRna-Binding Motif Protein 21Rna-Binding Protein 21U6 Snrna-Specific Terminal Uridylyltransferase 1U6-Tutase |
| Cellular Localisation | NucleusNucleolusNucleus Speckle |
| Alternative Antibody Names | Anti-Speckle Targeted Pip5k1a-Regulated Poly(A Polymerase antibodyAnti-Star-Pap antibodyAnti-Rna-Binding Motif Protein 21 antibodyAnti-Rna-Binding Protein 21 antibodyAnti-U6 Snrna-Specific Terminal Uridylyltransferase 1 antibodyAnti-U6-Tutase antibodyAnti-TUT1 antibodyAnti-RBM21 antibody |
Information sourced from Uniprot.org
