| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tubby-related protein 3 (257-307 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TULP3 |
| Gene ID: |
7289 |
| Uniprot ID: |
TULP3_HUMAN |
| Immunogen Region: |
257-307 aa |
| Specificity: |
This antibody detects endogenous levels of TULP3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TULP3 at the amino acid range 257-307 |
| Function | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. During adipogenesis, regulates ciliary trafficking of FFAR4 in preadipocytes. |
| Protein Name | Tubby-Related Protein 3Tubby-Like Protein 3 |
| Database Links | Reactome: R-HSA-5610787 |
| Cellular Localisation | NucleusCell MembraneCell ProjectionCiliumCytoplasmSecretedDoes Not Have A Cleavable Signal Peptide And Is Secreted By A Non-Conventional PathwayTranslocates From The Plasma Membrane To The Nucleus Upon Activation Of Guanine Nucleotide-Binding Protein G(Q) Subunit Alpha |
| Alternative Antibody Names | Anti-Tubby-Related Protein 3 antibodyAnti-Tubby-Like Protein 3 antibodyAnti-TULP3 antibodyAnti-TUBL3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
