Anti-TTYH2 antibody (319-369 aa) (STJ195464)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TTYH2 at the amino acid range 319-369
General Information
| Short Description | Rabbit polyclonal anti-Protein tweety homolog 2 (319-369 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TTYH2 |
| Gene ID | 94015 |
| Uniprot ID | TTYH2_HUMAN |
| Immunogen | Synthesized peptide derived from the human TTYH2 at the amino acid range 319-369 |
| Immunogen Region | 319-369 aa |
| Specificity | This antibody detects endogenous levels of TTYH2 at Human/Mouse |
Additional Info
| Post Translational Modifications | N- Glycosylated. Contains high-mannose, hybrid and complex oligosaccharides. Ubiquitinated by NEDD4L, leading to its proteasomal degradation. |
| Function | Calcium-independent, swelling-dependent volume-regulated anion channel (VRAC-swell) which plays a pivotal role in the process of regulatory volume decrease (RVD) in the brain through the efflux of anions like chloride and organic osmolytes like glutamate. Probable large-conductance Ca(2+)-activated chloride channel. |
| Protein Name | Protein Tweety Homolog 2Htty2Volume-Regulated Anion Channel Subunit Ttyh2 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Tweety Homolog 2 antibodyAnti-Htty2 antibodyAnti-Volume-Regulated Anion Channel Subunit Ttyh2 antibodyAnti-TTYH2 antibodyAnti-C17orf29 antibody |
Information sourced from Uniprot.org