| Tissue Specificity | Expressed in the retina, found in the rod and cone photoreceptors (at protein level). Widely expressed with highest levels in heart and skeletal muscle and low levels in other tissues. |
| Function | Polyglutamylase which modifies tubulin, generating polyglutamate side chains on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of tubulin. Preferentially mediates ATP-dependent initiation step of the polyglutamylation reaction over the elongation step. Preferentially modifies the alpha-tubulin tail over a beta-tail. Required for CCSAP localization to both polyglutamylated spindle and cilia microtubules. Increases the effects of transcriptional coactivator NCOA2/TIF2 in glucocorticoid receptor-mediated repression and induction and in androgen receptor-mediated induction. |
| Protein Name | Tubulin Polyglutamylase Ttll5Src1 And Tif2-Associated Modulatory ProteinStamp ProteinTubulin--Tyrosine Ligase-Like Protein 5 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | Cell ProjectionCiliumCytoplasmCytoskeletonCilium Basal BodyNucleusLocalized To The Base Of The Connecting Cilium Between The Basal Body And The Adjacent Daughter Centriole Of The CiliumIn Osteosarcoma CellsFound In Both Cytoplasm And Nucleus In The Absence Of Steroid But Located Exclusively In The Nucleus In The Presence Of Steroid |
| Alternative Antibody Names | Anti-Tubulin Polyglutamylase Ttll5 antibodyAnti-Src1 And Tif2-Associated Modulatory Protein antibodyAnti-Stamp Protein antibodyAnti-Tubulin--Tyrosine Ligase-Like Protein 5 antibodyAnti-TTLL5 antibodyAnti-KIAA0998 antibodyAnti-STAMP antibody |
Information sourced from Uniprot.org
