| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Tubulin monoglycylase TTLL3 (357-407 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TTLL3 |
| Gene ID: |
26140 |
| Uniprot ID: |
TTLL3_HUMAN |
| Immunogen Region: |
357-407 aa |
| Specificity: |
This antibody detects endogenous levels of TTLL3 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TTLL3 at the amino acid range 357-407 |
| Function | Monoglycylase which modifies alpha- and beta-tubulin, adding a single glycine on the gamma-carboxyl groups of specific glutamate residues to generate monoglycine side chains within the C-terminal tail of tubulin. Not involved in elongation step of the polyglycylation reaction. Preferentially glycylates a beta-tail peptide over the alpha-tail, although shifts its preference toward alpha-tail as beta-tail glutamylation increases. Competes with polyglutamylases for modification site on beta-tubulin substrate, thereby creating an anticorrelation between glycylation and glutamylation reactions. Together with TTLL8, mediates microtubule glycylation of primary and motile cilia, which is essential for their stability and maintenance. Involved in microtubule glycylation of primary cilia in colon which controls cell proliferation of epithelial cells and plays an essential role in colon cancer development. Together with TTLL8, glycylates sperm flagella which regulates axonemal dynein motor activity, thereby controlling flagellar beat, directional sperm swimming and male fertility. |
| Protein Name | Tubulin Monoglycylase Ttll3HottlTubulin--Tyrosine Ligase-Like Protein 3 |
| Database Links | Reactome: R-HSA-8955332 |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionCiliumCilium AxonemeFlagellum Axoneme |
| Alternative Antibody Names | Anti-Tubulin Monoglycylase Ttll3 antibodyAnti-Hottl antibodyAnti-Tubulin--Tyrosine Ligase-Like Protein 3 antibodyAnti-TTLL3 antibodyAnti-PRO0207 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
